📄 Category

hiv aids

53 papers

CD8+ T cell recall cytotoxicity during antiretroviral therapy is associated with limited HIV-1 reservoir size and activity

This study reveals that a subset of people with HIV on antiretroviral therapy possess highly functional CD8+ T cells capable of targeting autologous viral reservoirs, a phenomenon associated with smaller, less active reservoirs and the attenuation of viral rebound during treatment interruption, thereby highlighting the potential of immunotherapies to achieve durable HIV remission.

Collins, D. R., Olatotse, M. J., Urbach, J. M. + 23 more2026-03-01📄 hiv aids

Impact of violence on HIV outcomes among female sex workers: A global systematic review and meta-analysis

This global systematic review and meta-analysis of 91 studies involving nearly 180,000 female sex workers across 37 countries demonstrates that experiencing violence is significantly associated with higher odds of prevalent HIV infection and reduced odds of ART use and viral suppression, highlighting violence as a critical structural determinant that must be addressed in HIV interventions.

Dawe, J., Mazhar, K. A., Khan, S. A. + 10 more2026-02-27📄 hiv aids

Health and economic impact of geographically prioritized long-acting PrEP delivery in southern and eastern Africa

This study demonstrates that geographically prioritizing the delivery of long-acting injectable PrEP (Lenacapavir) to high-incidence districts in southern and eastern Africa significantly enhances its cost-effectiveness and impact, enabling efficient HIV prevention with limited resources by targeting specific demographic groups where incidence is highest.

Akullian, A., Imai-Eaton, J., Sharma, M. + 3 more2026-02-26📄 hiv aids

Utilizing pharmacy refill data to predict loss to follow-up among people living with HIV in Manyara region of Tanzania

This retrospective cohort study in Tanzania's Manyara region demonstrates that pharmacy refill adherence is a strong predictor of loss to follow-up among people living with HIV, revealing significant geographic disparities linked to nomadic lifestyles and highlighting the critical need for unique patient identifiers and mobility-friendly retention strategies to improve care continuity.

Kalulo, M. B., Sangeda, R. Z., Mwakyomo, J. + 3 more2026-02-26📄 hiv aids

The impact of USAID and CDC funding cuts on HIV incidence and mortality in KwaZulu Natal, South Africa

This study models the impact of abrupt USAID and CDC funding cuts in KwaZulu Natal, South Africa, revealing that such cessation would significantly increase HIV incidence and mortality by 2030, while restoring funds within 12 months and reallocating them to long-acting PrEP could substantially avert new infections and help realign the province with epidemic control goals.

Shenoi, S. V., Moll, A. P., Yoo, Y. R. + 12 more2026-02-22📄 hiv aids

PREVALENCE AND FACTORS ASSOCIATED WITH FALSE NEGATIVE RAPID DIAGNOSTIC HIV TESTS AMONG PATIENTS ON ANTIRETROVIRAL THERAPY WITH A NON-DETECTABLE VIRAL LOAD IN KAMPALA, UGANDA: A CROSS-SECTIONAL STUDY

This cross-sectional study conducted in Kampala, Uganda, reveals that approximately 3.2% of patients on antiretroviral therapy with undetectable viral loads yield false-negative results on rapid HIV diagnostic tests, a phenomenon significantly associated with higher CD4 counts and longer duration on treatment, suggesting that serial rapid testing alone may be insufficient for this population.

Nagawa, E., Nakiyingi, L., Kalyango, J. + 9 more2026-02-22📄 hiv aids

Trends in Healthcare Costs among People Living with HIV in Ontario, Canada, 2003-2018: Results from a Population-Based Retrospective Cohort Study

This population-based retrospective study in Ontario (2003–2018) reveals that annual mean healthcare costs for people living with HIV increased by approximately 40% driven primarily by medication expenditures, with significant cost disparities persisting among older adults, low-income residents, and those with advanced disease at diagnosis.

Xi, M., Dumicho, A. Y., Tan, D. H. S. + 8 more2026-02-19📄 hiv aids

Positive Running: a gender-transformative physical activity intervention to overcome intersectional barriers among adolescents with perinatally acquired HIV in India

This mixed-methods study in India demonstrates that while a peer-led running intervention improves mental health for adolescents with perinatally acquired HIV, its effectiveness is significantly hindered for girls by gendered social barriers, highlighting the urgent need for gender-transformative program designs to ensure equitable outcomes.

Sannigrahi, S., Filian, K., Seenappa, B. + 10 more2026-02-18📄 hiv aids

Determinants of HIV Testing Uptake Among Adolescent Girls and Young Women in Mainland Tanzania: A Stratified Analysis of the 2016/17 and 2022/2023 National Surveys

This study analyzes 2016/17 and 2022/23 national survey data to reveal that while HIV testing uptake among young women in mainland Tanzania increased from 86% to 90%, it stagnated at 40% for adolescents, with consistent determinants including union status, higher education, and STI history, underscoring the need for age-specific intervention strategies.

Kinoko, D. W., Kavindi, A. C., Yuda, P. + 4 more2026-02-16📄 hiv aids

Aligning Definitions with Realities: An Interpretive Descriptive Study on the Complexities of Measuring Retention in HIV Care in the Global Context

Using an interpretive descriptive methodology, this study explores how diverse global HIV stakeholders define and measure retention in care, concluding that flexible, patient-centred approaches aligned with specific objectives and contextual realities are superior to rigid, standardized metrics.

Rehman, N., Guyatt, G., Sabin, L. L. + 8 more2026-02-16📄 hiv aids

HIV Treatment and Program Preferences Among Ryan White Clients in New York City in the Era of Long-Acting Injectable ART: A Discrete Choice Experiment

A discrete choice experiment involving 200 Ryan White clients in New York City revealed that a majority prefer long-acting injectable HIV treatment over daily pills, particularly among younger, Latino, and non-heterosexual individuals, despite limited prior familiarity with this regimen.

Zimba, R., Kelvin, E. A., Kulkarni, S. + 6 more2026-02-16📄 hiv aids